Jones B E
Neurosci Lett. 1979 Aug;13(3):285-93. doi: 10.1016/0304-3940(79)91508-8.
Bilateral lesions of the pontine gigantocellular tegmental field in the cat resulted in the complete elimination of paradoxical sleep during 3 weeks postoperative recording. The tonic muscular atonia, normally characteristic of this state, was absent. The phasic components, rapid eye movements and ponto-geniculooccipital (PGO) spikes, did not occur in association with an activated EEG, as they normally do in paradoxical sleep. In fact, PGO spikes were virtually absent immediately after the lesion and were only secondarily apparent as isolated phenomena during slow wave sleep to represent in total daily number 5% of normal the first week and 15% of normal the third week after the lesion. These results indicate that neurons whose perikarya and/or processes are located within the pontine gigantocellular tegmental field and which are not part of the noradrenaline locus coeruleus complex, are critical for paradoxical sleep.
猫脑桥巨细胞被盖区的双侧损伤导致术后3周记录期间异相睡眠完全消失。通常这种状态所特有的紧张性肌肉弛缓不存在了。与激活的脑电图相关联的位相成分，即快速眼动和脑桥-膝-枕（PGO）峰电位，不像它们在异相睡眠中通常出现的那样发生。实际上，损伤后PGO峰电位立即几乎完全消失，只是在慢波睡眠期间作为孤立现象在损伤后第一周占正常总量的5%，第三周占正常总量的15%才继发显现出来。这些结果表明，其胞体和/或突起位于脑桥巨细胞被盖区且不属于去甲肾上腺素蓝斑复合体一部分的神经元，对异相睡眠至关重要。
