Tyrrell R N, Lane J G, Nancarrow C D, Connell P J
Aust Vet J. 1981 Feb;57(2):76-8. doi: 10.1111/j.1751-0813.1981.tb00450.x.
Of 87 Dorset ewes injected at 20 to 60 days of pregnancy with either 125 micrograms or 250 micrograms of the prostaglandin F2 alpha analogue, cloprostenol, 72 (83%) were detected in oestrus by teaser rams within 7 days. A total of 60 ewes mated with fertile rams 14 to 28 days after treatment and 36 of these (60%) subsequently lambed. Thirty-eight ewes mated with fertile rams 29 to 56 days after treatment and 30 of these (79%) subsequently lambed. The difference in fertility between the 2 periods was not significant. Six additional ewes which did not respond to the cloprostenol lambed normally within 6 weeks. They were more than 100 days pregnant when treated. In ewes which first exhibited oestrus by 7 days of treatment, plasma progesterone concentrations fell from near 4 ng/ml to 0.6 ng/ml within 48 h of treatment. In ewes not detected in oestrus progesterone concentrations did not decrease to similar low levels (1.4 ng/ml; t-test p less than 0.005). Concentrations in the 6 ewes treated near 100 days of pregnancy dropped from 7.4 to 4.4 ng/ml over 48 h. Overall, the progesterone concentrations indicated that 92% of ewes treated at 20 to 60 days of pregnancy experienced rapid luteolysis in response to the cloprostenol. There were no differences between the 2 doses of cloprostenol in the responses or subsequent fertility of the ewes.
在怀孕20至60天的87只多塞特母羊中，注射125微克或250微克前列腺素F2α类似物氯前列醇后，72只（83%）在7天内被试情公羊检测到发情。总共60只母羊在治疗后14至28天与可育公羊交配，其中36只（60%）随后产羔。38只母羊在治疗后29至56天与可育公羊交配，其中30只（79%）随后产羔。这两个时期的繁殖力差异不显著。另外6只对氯前列醇无反应的母羊在6周内正常产羔。治疗时它们已怀孕超过100天。在治疗7天内首次发情的母羊中，血浆孕酮浓度在治疗后48小时内从近4纳克/毫升降至0.6纳克/毫升。未检测到发情的母羊中，孕酮浓度未降至类似的低水平（1.4纳克/毫升；t检验p<0.005）。在怀孕近100天时接受治疗的6只母羊的浓度在48小时内从7.4降至4.4纳克/毫升。总体而言，孕酮浓度表明，怀孕20至60天接受治疗的母羊中有92%对氯前列醇有反应，出现快速黄体溶解。两种剂量的氯前列醇在母羊的反应或随后的繁殖力方面没有差异。
