von Rottkay P, Lössl H J, Böhm O
Strahlentherapie. 1978 Dec;154(12):820-9.
41 patients were submitted to telecobalt irradiations of the prostate and the adjoining lymph drain regions. The absence of remote metastases was verified by X-ray examinations of the skeleton and bone scintigrams, and stades were divided by means of lymphography. The overall 3,5-year survival rate was 79.9%, the 3,5-year survival rate of the patients without lymph node metastases was 100% and that of the group with lymph node metastases was 25%. 69,6% of all patients had no recurrences after 3.5 years, the corresponding rate for the patients without lymph node metastases was 84% and that for the patients with lymph node metastases was 24.6%. The difference between patients with and patients without lymph node metastases demonstrated by lymphography was statistically significant and decisive for the prognosis. The clinically judged local tumor control was 100% for those patients who were observed during a period of more than one year after the radiotherapy. Lymph nodes which were also irradiated underwent an involution in all cases. Different differentiation degrees responded in the same way to radiotherapy. A dependence of rectal complications on the dose could be demonstrated. The results were not ameliorated by additional hormonal therapy.
41例患者接受了前列腺及相邻淋巴引流区域的远距离钴照射。通过骨骼X线检查和骨闪烁扫描证实无远处转移，并通过淋巴造影对分期进行划分。总体3.5年生存率为79.9%，无淋巴结转移患者的3.5年生存率为100%，有淋巴结转移组的生存率为25%。3.5年后，所有患者中有69.6%无复发，无淋巴结转移患者的相应比例为84%，有淋巴结转移患者的比例为24.6%。淋巴造影显示有淋巴结转移患者与无淋巴结转移患者之间的差异具有统计学意义，对预后起决定性作用。放疗后观察一年以上的患者，临床判断局部肿瘤控制率为100%。所有接受照射的淋巴结均出现萎缩。不同分化程度对放疗的反应相同。可以证明直肠并发症与剂量有关。额外的激素治疗并未改善结果。
