Molecular pharmacology of the haloethyl nitrosoureas: formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N1-bis[2-chloroethyl]-N-nitrosourea).

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作者信息

Tong W P, Kirk M C, Ludlum D B

出版信息

Biochem Biophys Res Commun. 1981 May 15;100(1):351-7. doi: 10.1016/s0006-291x(81)80103-9.

DOI:10.1016/s0006-291x(81)80103-9

PMID:7259755

Abstract

摘要

相似文献

Molecular pharmacology of the haloethyl nitrosoureas: formation of 6-hydroxyethylguanine in DNA treated with BCNU (N,N1-bis[2-chloroethyl]-N-nitrosourea).

Biochem Biophys Res Commun. 1981 May 15;100(1):351-7. doi: 10.1016/s0006-291x(81)80103-9.

Formation of the cross-linked base, diguanylethane, in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.在用N，N'-双（2-氯乙基）-N-亚硝基脲处理的DNA中形成交联碱基二鸟苷乙烷。

Cancer Res. 1981 Feb;41(2):380-2.

Mechanism of action of the nitrosoureas--V. Formation of O6-(2-fluoroethyl)guanine and its probable role in the crosslinking of deoxyribonucleic acid.亚硝基脲类的作用机制——V. O6-(2-氟乙基)鸟嘌呤的形成及其在脱氧核糖核酸交联中的可能作用

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Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.在用N，N'-双（2-氯乙基）-N-亚硝基脲处理的DNA中形成交联物1-[N3-脱氧胞苷基]，2-[N1-脱氧鸟苷基]乙烷。

Cancer Res. 1982 Aug;42(8):3102-5.

Mechanism of action of the nitrosoureas: formation of 1,2-(diguanosin-7-yl) ethane from the reaction of BCNU (1,3-bis-[2-chloroethyl]-1-nitrosourea) with guanosine.亚硝基脲类的作用机制：BCNU（1,3-双-[2-氯乙基]-1-亚硝基脲）与鸟苷反应生成1,2-（二鸟苷-7-基）乙烷。

Biochem Biophys Res Commun. 1979 Oct 12;90(3):878-82. doi: 10.1016/0006-291x(79)91909-0.

Mechanism of action of (2-haloethyl)nitrosoureas on DNA. Isolation and reactions of postulated 2-(alkylimino)-3-nitrosooxazolidine intermediates in the decomposition of 1,3-bis(2-chloroethyl)-, 1-(2-chloroethyl)-3-cyclohexyl-, and 1-(2-chloroethyl)-3-(4'-trans-methylcyclohexyl)-1-nitrosourea.（2-卤代乙基）亚硝基脲对DNA的作用机制。1,3-双（2-氯乙基）-、1-（2-氯乙基）-3-环己基-和1-（2-氯乙基）-3-（4'-反式甲基环己基）-1-亚硝基脲分解过程中假定的2-（烷基亚氨基）-3-亚硝基恶唑烷中间体的分离与反应。

J Med Chem. 1981 Mar;24(3):270-9. doi: 10.1021/jm00135a007.

Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas.1,3-双（2-氯乙基）-1-亚硝基脲及其他1-（2-卤乙基）-1-亚硝基脲对DNA的链间交联作用。

Cancer Res. 1977 May;37(5):1450-4.

Modifications of DNA by different haloethylnitrosoureas.不同卤代乙基亚硝基脲对DNA的修饰作用。

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J Med Chem. 1976 Jul;19(7):958-61. doi: 10.1021/jm00229a019.

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