Savvateev K L, Shinbaeva N A, Vygodin V A, Nikolenko S A
Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1981;4(1):64-70.
The effect of Korinfar (30 and 50 mg) and isoptin (120 and 200 mg) on exercise tolerance was studied in 11 patients with angina pectoris of effort using the double blind crossover method. Both doses of Korinfar and 120 mg of isoptin increased cardiac output by 70--80% and 200 mg of isoptin--by 136%. Korinfar had a pronounced growth hypotensive effect and induced tachycardia, which is an increased dose hindered growth of exercise tolerance. The negative chronotropic effect of isoptin increased its efficacy. As a result of calcium antagonists action a stable threshold double product was established, and its was higher, than the control one.
采用双盲交叉法，对11例劳力性心绞痛患者研究了科立福（30毫克和50毫克）和异搏定（120毫克和200毫克）对运动耐力的影响。科立福的两种剂量以及120毫克异搏定可使心输出量增加70% - 80%，200毫克异搏定可使心输出量增加136%。科立福有明显的降压作用并诱发心动过速，剂量增加会阻碍运动耐力的提高。异搏定的负性变时作用增强了其疗效。由于钙拮抗剂的作用，建立了稳定的阈值双乘积，且高于对照组。
