Aprille J R, Yaswen P, Rulfs J
Biochim Biophys Acta. 1981 Jun 11;675(1):143-7. doi: 10.1016/0304-4165(81)90080-5.
The total adenine nucleotide content of the mitochondrial matrix increases 3--4-fold within a few hours of birth in rat liver. This provides a mechanism for the acute postnatal regulation of pyruvate carboxylase, which is located in the matrix compartment and which requires ATP as a substrate. The sudden increase in pyruvate carboxylase activity is proposed to account for a rapid 4--5-fold increase in the gluconeogenic rate of the newborn rat.
大鼠肝脏在出生后的几个小时内，线粒体基质中的腺嘌呤核苷酸总量增加3至4倍。这为丙酮酸羧化酶的产后急性调节提供了一种机制，丙酮酸羧化酶位于基质区室，且需要ATP作为底物。丙酮酸羧化酶活性的突然增加被认为是新生大鼠糖异生速率迅速增加4至5倍的原因。
