Jones L V, Whitehouse M J
Biomed Mass Spectrom. 1981 May;8(5):231-6. doi: 10.1002/bms.1200080508.
Recent trends towards increasing abuse of the barbiturates has led to a proposal to legally restrict some of them. The implementation of the resulting legislation might require specific identification of the barbiturates. Such identification is not readily available from electron impact mass spectra and, even when these are supplemented with chemical ionization data, barbiturates differing only in isomeric sidechains are not completely characterized. In this study the anion mass spectra of 30 barbiturates, including all of those commonly available, are presented. The spectra are simple; ions arising from hydrogen atom and sidechain elimination from the initially formed [M]- ion are diagnostic of the barbiturate. For all but two of the barbiturates (butalbital and idobutal) relative peak intensities will discriminate between barbiturates differing only in isomeric sidechains.
近期巴比妥类药物滥用现象日益增多，这导致了一项关于对其中一些药物进行法律限制的提议。由此产生的立法实施可能需要对巴比妥类药物进行特定识别。电子轰击质谱无法轻易提供这种识别，即使辅以化学电离数据，仅在异构侧链上有所不同的巴比妥类药物也无法得到完全表征。在本研究中，展示了30种巴比妥类药物的负离子质谱，其中包括所有常见的药物。这些质谱很简单；最初形成的[M]⁻离子消除氢原子和侧链产生的离子可用于诊断巴比妥类药物。除了两种巴比妥类药物（布他比妥和异丁巴比妥）外，相对峰强度能够区分仅在异构侧链上不同的巴比妥类药物。
