Perevozchikova M F
Biull Eksp Biol Med. 1981 Apr;91(4):469-71.
Radiometry was used to assay myelinization and demyelinization in organotypic long-surviving cultures of the cerebellum from newborn rats. It was shown that serum from guinea-pigs with allergic encephalomyelitis suppresses by 45% the incorporation of labeled cholesterol into nerve tissue cells in the early periods of cultivation (within 10 days), i.e. before myelinization commencement. It also suppresses thymidine and cholesterol incorporation in the later periods of cultivation, i.e. in the last stages of differentiation, this suppression being increased twofold in the myelinized cultures of the nerve tissue. The effect of humoral factors of the sera from sick animals on the neuroglial cells in the course of nerve tissue differentiation in vitro is discussed.
采用放射测量法对新生大鼠小脑的器官型长期存活培养物中的髓鞘形成和脱髓鞘进行分析。结果表明，患有过敏性脑脊髓炎的豚鼠血清在培养早期（10天内），即髓鞘形成开始前，可使标记胆固醇掺入神经组织细胞的量减少45%。在培养后期，即分化的最后阶段，它还会抑制胸腺嘧啶核苷和胆固醇的掺入，在神经组织的髓鞘化培养物中这种抑制作用会增加一倍。文中讨论了患病动物血清中的体液因子在体外神经组织分化过程中对神经胶质细胞的作用。
