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真性红细胞增多症的长期培养作为对促红细胞生成素依赖性的证据(作者译)

[Long-term cultures in polycythaemia vera as proof for dependence on erythropoietin (author's transl)].

作者信息

Heilmann E, Holzknecht A, Fahrenkrug H, Essers U

出版信息

Blut. 1981 Jul;43(1):51-6. doi: 10.1007/BF00319932.

Abstract

In eight patients suffering from polycythaemia vera, the proliferation of erythroid colonies in methylcellulose with and without exogenous erythropoietin was studied. After three and five weeks, respectively, no colonies grew. Due to addition of erythropoietin more erythroid colonies proliferated which could be cultivated over nine weeks. The experiments suggest that the erythropoiesis in polycythaemia vera depends on erythropoietin.

摘要

对8例真性红细胞增多症患者,研究了有无外源性促红细胞生成素时甲基纤维素中红系集落的增殖情况。分别在3周和5周后,均无集落生长。由于添加了促红细胞生成素,更多的红系集落得以增殖,并可持续培养9周。这些实验提示,真性红细胞增多症中的红细胞生成依赖于促红细胞生成素。

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