γ-羟基丁酸的个体发生。I. 发育中大鼠、猴子和人类大脑的区域浓度。

Ontogeny of gamma-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brain.

作者信息

Snead O C, Morley B J

出版信息

Brain Res. 1981 Jul;227(4):579-89. doi: 10.1016/0165-3806(81)90010-9.

Abstract

Steady state levels of gamma-hydroxybutyrate (GHB) were measured in whole brain and discrete regions of brain in developing and adult rat, monkey, and human brain. Postmortem changes in concentration of GHB in rat and human brain were also assessed. There were no significant postmortem changes in GHB under the conditions which the ontogeny experiments were done. The concentration of GHB was uniformly higher in the immature brains of the 3 species studied. In the rat the highest concentration was in immature hypothalamus and cortex with a significant decrease occurring between postnatal day 12 and 14. In human, the highest concentration was in fetal cerebellum and adult hypothalamus. Comparison of these data with published ontogeny data for gamma-aminobutyric acid (GABA) suggest that there may be a source of GHB in brain other than GABA.

摘要

在发育中的和成年大鼠、猴子及人类大脑中，测量了全脑及大脑离散区域中γ-羟基丁酸（GHB）的稳态水平。还评估了大鼠和人类大脑中GHB浓度的死后变化。在进行个体发育实验的条件下，GHB没有显著的死后变化。在所研究的3个物种的未成熟大脑中，GHB的浓度均较高。在大鼠中，最高浓度出现在未成熟的下丘脑和皮层，在出生后第12天至14天之间显著下降。在人类中，最高浓度出现在胎儿小脑和成年下丘脑。将这些数据与已发表的γ-氨基丁酸（GABA）个体发育数据进行比较表明，大脑中可能存在除GABA之外的GHB来源。