Swell L, Gustafsson J, Danielsson H, Schwartz C C, Halloran L G, Vlahcevic Z R
Cancer Res. 1981 Sep;41(9 Pt 2):3757-8.
Metabolic pathways involved in the conversion of cholesterol to cholic and chenodeoxycholic acids have been investigated in bile fistula patients treated with a number of labeled potential bile acid intermediates. The findings of the present report indicate that the human liver cell has the capacity to synthesize both primary bile acids via multiple routes from cholesterol and 7 alpha-hydroxycholesterol. Evidence has been obtained for the existence of a major pathway to chenodeoxycholic acid via the 26-hydroxylation of 7 alpha-hydroxycholest-4-en-3-one. Cholic acid is synthesized preferentially via pathways from 5 beta-cholestane 3 alpha, 7 alpha-diol and a pathway from cholesterol not involving an initial 7 alpha-hydroxylation.
在使用多种标记的潜在胆汁酸中间体治疗的胆瘘患者中，已对胆固醇转化为胆酸和鹅去氧胆酸所涉及的代谢途径进行了研究。本报告的研究结果表明，人类肝细胞有能力通过多种途径从胆固醇和7α-羟基胆固醇合成两种初级胆汁酸。已经获得证据表明，存在一条通过7α-羟基胆甾-4-烯-3-酮的26-羟基化生成鹅去氧胆酸的主要途径。胆酸优先通过5β-胆甾烷3α,7α-二醇途径以及一条不涉及初始7α-羟基化的胆固醇途径合成。
