Koiwaya Y, Ashihara T, Nakamura M, Etoh A
Clin Ther. 1981;3(6):436-40.
The plasma concentration and hemodynamics of diltiazem after oral administration of 90 mg were studied in nine normal volunteers. Diltiazem was rapidly absorbed within three hours, and mean peak plasma concentration was 93.3 +/- 12.6 ng/ml (mean +/- SE). The plasma level gradually declined soon after, and almost no diltiazem was determined in 24-hours. Heart rate and blood pressure decreased slightly but significantly (P less than 0.001 and P less than 0.005, respectively). No prolongation of PR interval was demonstrated.
在9名正常志愿者中研究了口服90毫克地尔硫䓬后的血浆浓度和血流动力学。地尔硫䓬在3小时内迅速吸收，平均血浆峰浓度为93.3±12.6纳克/毫升（平均值±标准误）。此后血浆水平很快逐渐下降，24小时内几乎检测不到地尔硫䓬。心率和血压略有下降但具有显著意义（分别为P<0.001和P<0.005）。未显示PR间期延长。
