Wopfner F
Dtsch Med Wochenschr. 1981 Aug 28;106(35):1099-102. doi: 10.1055/s-2008-1070463.
Intra-arterial liver perfusion of cytostatic drugs via an indwelling double-lumen polyurethane catheter was undertaken in 17 patients with diffuse metastases involving 50-70% of the liver and previously treated by radical local resections. Treatment continued over 3-20 months (mean 8.4 months). In ten patients with colorectal carcinoma treatment lasted for 7 months, follow-up for a mean of 14 months (range 5-24 months), and the one-year survival time (using the actuarial method) was 79 +/- 26%. The toxicity was well controllable. It is concluded that this form of treatment improves quality of life in such patients.
通过留置双腔聚氨酯导管对17例肝脏弥漫性转移患者进行细胞毒性药物肝动脉灌注治疗,这些患者肝脏转移灶累及50%-70%,且之前接受过根治性局部切除。治疗持续3-20个月(平均8.4个月)。10例结直肠癌患者治疗持续7个月,随访平均14个月(范围5-24个月),1年生存时间(采用精算方法)为79±26%。毒性易于控制。结论是这种治疗方式可改善此类患者的生活质量。