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不可切除性肝转移瘤的治疗:通过新型留置导管进行肝内化疗的初步结果(作者译)

[Treatment of inoperable liver metastases: preliminary results with intrahepatic chemotherapy via a new type of indwelling catheter (author's transl)].

作者信息

Wopfner F

出版信息

Dtsch Med Wochenschr. 1981 Aug 28;106(35):1099-102. doi: 10.1055/s-2008-1070463.

DOI:10.1055/s-2008-1070463
PMID:7261935
Abstract

Intra-arterial liver perfusion of cytostatic drugs via an indwelling double-lumen polyurethane catheter was undertaken in 17 patients with diffuse metastases involving 50-70% of the liver and previously treated by radical local resections. Treatment continued over 3-20 months (mean 8.4 months). In ten patients with colorectal carcinoma treatment lasted for 7 months, follow-up for a mean of 14 months (range 5-24 months), and the one-year survival time (using the actuarial method) was 79 +/- 26%. The toxicity was well controllable. It is concluded that this form of treatment improves quality of life in such patients.

摘要

通过留置双腔聚氨酯导管对17例肝脏弥漫性转移患者进行细胞毒性药物肝动脉灌注治疗,这些患者肝脏转移灶累及50%-70%,且之前接受过根治性局部切除。治疗持续3-20个月(平均8.4个月)。10例结直肠癌患者治疗持续7个月,随访平均14个月(范围5-24个月),1年生存时间(采用精算方法)为79±26%。毒性易于控制。结论是这种治疗方式可改善此类患者的生活质量。

相似文献

1
[Treatment of inoperable liver metastases: preliminary results with intrahepatic chemotherapy via a new type of indwelling catheter (author's transl)].不可切除性肝转移瘤的治疗:通过新型留置导管进行肝内化疗的初步结果(作者译)
Dtsch Med Wochenschr. 1981 Aug 28;106(35):1099-102. doi: 10.1055/s-2008-1070463.
2
[Treatment of inoperable liver metastasis. Preliminary results with intrahepatic chemotherapy via a new type of indwelling catheter].
Minerva Chir. 1982 Sep 15;37(17):1337-40.
3
Hepatic arterial chemotherapy with oxaliplatin, folinic acid and 5-fluorouracil in pre-treated patients with liver metastases from colorectal cancer.奥沙利铂、亚叶酸钙和5-氟尿嘧啶肝动脉化疗用于经治的结直肠癌肝转移患者
In Vivo. 2006 Nov-Dec;20(6A):743-6.
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Outcomes of hepatic artery infusion therapy for hepatic metastases from colorectal carcinoma after radiological placement of infusion catheters.经放射学方法放置输注导管后,肝动脉灌注治疗结直肠癌肝转移的疗效。
Eur J Surg Oncol. 2007 Aug;33(6):741-5. doi: 10.1016/j.ejso.2007.02.012. Epub 2007 Mar 30.
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Adjuvant hepatic arterial infusion after curative resection of colorectal liver metastases using removable intra-arterial catheters with shape-memory alloy.使用形状记忆合金可移除动脉内导管对结直肠癌肝转移灶进行根治性切除术后的辅助性肝动脉灌注
J Surg Oncol. 2004 Dec 15;88(4):248-55. doi: 10.1002/jso.20159.
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A novel arterial infusion chemotherapy for the treatment of patients with advanced pancreatic carcinoma after vascular supply distribution via superselective embolization.一种新型动脉灌注化疗,用于经超选择性栓塞进行血管供应分布后治疗晚期胰腺癌患者。
Cancer. 2000 Jul 15;89(2):303-13.
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[Home treatment of cancer: experiences with ambulatory intra-arterial chemotherapy of liver metastases].
Schweiz Med Wochenschr. 1987 Sep 5;117(36):1342-6.
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Hepatic arterial infusion chemotherapy through a port-catheter system as preoperative initial therapy in patients with advanced liver dysfunction due to synchronous and unresectable liver metastases from colorectal cancer.通过端口导管系统进行肝动脉灌注化疗,作为因结直肠癌同步性且不可切除肝转移导致晚期肝功能不全患者的术前初始治疗。
Cardiovasc Intervent Radiol. 2008 Jan-Feb;31(1):86-90. doi: 10.1007/s00270-007-9189-0. Epub 2007 Oct 10.
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[Clinical experience of intra-arterial chemotherapy for liver metastases of breast cancer patients].[乳腺癌患者肝转移动脉内化疗的临床经验]
Gan To Kagaku Ryoho. 2001 Oct;28(11):1780-2.
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Phase II feasibility study on the combination of two different regional treatment approaches in patients with colorectal "liver-only" metastases: hepatic interstitial brachytherapy plus regional chemotherapy.两种不同区域治疗方法联合用于结直肠癌“仅肝转移”患者的II期可行性研究:肝间质近距离放射治疗联合区域化疗
Cardiovasc Intervent Radiol. 2009 Sep;32(5):937-45. doi: 10.1007/s00270-009-9597-4. Epub 2009 May 27.

引用本文的文献

1
Liver regional continuous chemotherapy: use of femoral or subclavian artery for percutaneous implantation of catheter-port systems.肝脏区域持续化疗:经皮穿刺股动脉或锁骨下动脉植入导管-药盒系统的应用。
World J Gastroenterol. 2004 Jun 1;10(11):1659-62. doi: 10.3748/wjg.v10.i11.1659.