Mushtaq M, Mukhtar H, Datta K K, Tandon S G, Seth P K
Drug Chem Toxicol. 1981;4(1):75-88. doi: 10.3109/01480548109066373.
Toxicological studies of a leachable stabilizer Di-n-butyltin dilaurate (DBTL) were undertaken. Effects of DBTL after 15 days oral exposure to rats were studied on brain and liver enzyme activities. A significant decrease in body weight gain of DBTL exposed rats were observed. No effect was observed in the activities of brain enzymes, succinic dehydrogenase, adenosine triphosphatase, acetylcholine esterase and monoamine oxidase. In liver, DBTL treatment resulted in a significant decrease in the activities of microsomal enzymes glucose-6-phosphatase, aminopyrine-N-demethylase, benzphetamine-N-demethylase, aniline hydroxylase, benzo(a)pyrene hydroxylase and also on cytochrome P-450 content, whereas no difference in the activities of mitochondrial enzymes, succinic dehydrogenase, Mg2+-adenosine triphosphatase as well as in the activity of lysosomal enzyme acid phosphatase was observed. Duration of exposure dependent increase in pentabarbital induced sleeping time was also observed. DBTL treatment produced an induction in heme oxygenase activity whereas the activity of -aminolevulinic acid synthetase remained unaltered. The results demonstrate that DBTL significantly affects the biotransformation mechanism and heme metabolism of hepatocytes.
开展了一种可浸出稳定剂二月桂酸二正丁基锡（DBTL）的毒理学研究。研究了DBTL对大鼠口服暴露15天后大脑和肝脏酶活性的影响。观察到DBTL暴露大鼠的体重增加显著下降。在大脑酶、琥珀酸脱氢酶、三磷酸腺苷酶、乙酰胆碱酯酶和单胺氧化酶的活性方面未观察到影响。在肝脏中，DBTL处理导致微粒体酶葡萄糖-6-磷酸酶、氨基比林-N-脱甲基酶、苄非他明-N-脱甲基酶、苯胺羟化酶、苯并(a)芘羟化酶的活性以及细胞色素P-450含量显著下降，而在线粒体酶、琥珀酸脱氢酶、Mg2+-三磷酸腺苷酶的活性以及溶酶体酶酸性磷酸酶的活性方面未观察到差异。还观察到戊巴比妥诱导的睡眠时间随暴露时间的增加而延长。DBTL处理导致血红素加氧酶活性诱导，而δ-氨基乙酰丙酸合成酶的活性保持不变。结果表明，DBTL显著影响肝细胞的生物转化机制和血红素代谢。
