Dodman N H, Waterman A E
Vet Rec. 1978 Oct 7;103(15):334-5. doi: 10.1136/vr.103.15.334.
The effectiveness of naloxone hydrochloride in reversing Immobilon anaesthesia was evaluated in 14 dogs. Although a dose rate of 0.02 mg per kg body-weight briefly reversed the respiratory and cardiovascular depression, a dose of at least 0.6 mg per kg body-weight was required before full recovery of consciousness occurred. The action of naloxone was found to be relatively short lived and relapse tended to occur after 10 to 15 minutes. The implications of these findings are discussed in relation to the use of naloxone in the event of accidental self-administration of Immobilon in man.
在14只犬中评估了盐酸纳洛酮逆转因Immobilon产生的麻醉作用的效果。虽然每千克体重0.02毫克的剂量率能短暂逆转呼吸和心血管抑制，但在意识完全恢复之前，每千克体重至少需要0.6毫克的剂量。发现纳洛酮的作用持续时间相对较短，10至15分钟后往往会复发。结合人类意外自行使用Immobilon时纳洛酮的使用情况，讨论了这些发现的意义。
