Den K, Tomita M, Miyake Y, Yamaguchi N, Fukasawa M, Teramoto K, Takagi S
Endocrinol Jpn. 1980 Dec;27(6):703-8. doi: 10.1507/endocrj1954.27.703.
Simultaneous determination of maternal and fetal plasma 11-deoxycorticosterone (DOC), corticosterone (B), 18-hydroxycorticosterone (18OH-B) and aldosterone (ALDO) in normal and toxemic pregnancies was performed by utilizing a newly developed radioimmunoassay. The mean levels of plasma DOC and ALDO in normal term pregnancy were significantly higher than those of nonpregnant women. Comparing the mean levels of umbilical arterial plasma to those in maternal plasma at delivery, DOC and ALDO were consistently higher in the former, while B was higher in the latter, and 18OH-B was largely unchanged. However, no umbilical arteriovenous gradient was found in any corticosteroid measured. In toxemia of pregnancy, the corticosteroid levels in the maternal plasma were lower than those in normal pregnancies, and in umbilical arterial plasma, B was significantly higher and 18OH-B and ALDO remained almost the same as those in normal pregnancy. Thus, it appears that ALDO synthesis in mother in normal term pregnancy was enhanced but in toxemia of pregnancy it was suppressed, while in the fetus, it was enhanced not only in normal pregnancy but also in toxemia of pregnancy.
利用新开发的放射免疫分析法同时测定正常妊娠和中毒妊娠母体及胎儿血浆中的11-脱氧皮质酮（DOC）、皮质酮（B）、18-羟皮质酮（18OH-B）和醛固酮（ALDO）。足月正常妊娠血浆中DOC和ALDO的平均水平显著高于未怀孕女性。将分娩时脐动脉血浆的平均水平与母体血浆的平均水平进行比较，前者的DOC和ALDO一直较高，而后者的B较高，且18OH-B基本无变化。然而，在所检测的任何一种皮质类固醇中均未发现脐动静脉梯度。在妊娠中毒症中，母体血浆中的皮质类固醇水平低于正常妊娠，而在脐动脉血浆中，B显著升高，18OH-B和ALDO与正常妊娠时几乎相同。因此，似乎足月正常妊娠时母体中的ALDO合成增强，但在妊娠中毒症时受到抑制，而在胎儿中，不仅在正常妊娠时增强，在妊娠中毒症时也增强。
