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血管活性肠肽(VIP)对视网膜腺苷酸环化酶的刺激作用。

Stimulation of retinal adenylate cyclase by vasoactive intestinal peptide (VIP).

作者信息

Longshore M A, Makman M H

出版信息

Eur J Pharmacol. 1981 Mar 12;70(2):237-40. doi: 10.1016/0014-2999(81)90220-x.

DOI:10.1016/0014-2999(81)90220-x
PMID:7262187
Abstract

The effects of vasoactive intestinal peptide (VIP), secretin and glucagon on retinal adenylate cyclase were studied in rabbit, rat and calf retinas. The results demonstrate the presence of a highly active VIP sensitive adenylate cyclase in mammalian retina. The effects are not enhanced by the guanine nucleotide analog 5'-guanylylimidodiphosphate (Gpp(NH)p). Glucagon and secretin also caused significant increases in retinal adenylate cyclase activity although, in general, the magnitude of these effects was less than that of VIP.

摘要

在兔、大鼠和小牛视网膜中研究了血管活性肠肽(VIP)、促胰液素和胰高血糖素对视网膜腺苷酸环化酶的影响。结果表明,哺乳动物视网膜中存在一种高活性的VIP敏感腺苷酸环化酶。鸟嘌呤核苷酸类似物5'-鸟苷酰亚胺二磷酸(Gpp(NH)p)不会增强这些作用。胰高血糖素和促胰液素也可使视网膜腺苷酸环化酶活性显著增加,不过总体而言,这些作用的程度小于VIP。

相似文献

1
Stimulation of retinal adenylate cyclase by vasoactive intestinal peptide (VIP).血管活性肠肽(VIP)对视网膜腺苷酸环化酶的刺激作用。
Eur J Pharmacol. 1981 Mar 12;70(2):237-40. doi: 10.1016/0014-2999(81)90220-x.
2
Characterization of the VIP- and secretin-stimulated adenylate cyclase system from human lung.人肺中血管活性肠肽和促胰液素刺激的腺苷酸环化酶系统的特性
Pflugers Arch. 1981 Sep;391(3):178-82. doi: 10.1007/BF00596167.
3
Secretin and VIP-stimulated adenylate cyclase from rat heart. II. Impairment in spontaneous hypertension.大鼠心脏中促胰液素和血管活性肠肽刺激的腺苷酸环化酶。II. 自发性高血压中的损伤
Pflugers Arch. 1980 Dec;389(1):29-35. doi: 10.1007/BF00587925.
4
Impairment of hormone-stimulated cardiac adenylate cyclase activity in the genetically obese (fa/fa) Zucker rat.遗传性肥胖(fa/fa) Zucker大鼠中激素刺激的心脏腺苷酸环化酶活性受损。
Pflugers Arch. 1981 Apr;390(1):10-6. doi: 10.1007/BF00582704.
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Secretin and VIP-stimulated adenylate cyclase from rat heart. I. General properties and structural requirements for enzyme activation.大鼠心脏中促胰液素和血管活性肠肽刺激的腺苷酸环化酶。I. 酶激活的一般特性和结构要求
Pflugers Arch. 1980 Dec;389(1):21-7. doi: 10.1007/BF00587924.
6
Heart receptors for VIP, PHI and secretin are able to activate adenylate cyclase and to mediate inotropic and chronotropic effects. Species variations and physiopathology.血管活性肠肽、胰高血糖素样肽和促胰液素的心脏受体能够激活腺苷酸环化酶并介导变力性和变时性效应。物种差异与病理生理学。
Peptides. 1984 Mar-Apr;5(2):341-53. doi: 10.1016/0196-9781(84)90232-8.
7
Interactions between vasoactive intestinal peptide and dopamine in the rabbit retina: stimulation of a common adenylate cyclase.血管活性肠肽与多巴胺在兔视网膜中的相互作用:对共同腺苷酸环化酶的刺激作用
J Neurochem. 1986 Jan;46(1):257-64. doi: 10.1111/j.1471-4159.1986.tb12955.x.
8
Effect of secretin, glucagon and vasoactive intestinal peptide on the hormone-sensitive rat cardiac adenylate cyclase [proceedings].
Arch Int Physiol Biochim. 1979 Oct;87(4):783-4.
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Potentiation by guanine nucleotides of the VIP-induced adenylate cyclase stimulation in intestinal epithelial cell membranes.鸟嘌呤核苷酸对肠上皮细胞膜中血管活性肠肽诱导的腺苷酸环化酶刺激作用的增强效应。
Life Sci. 1980 Jun 2;26(22):1905-11. doi: 10.1016/0024-3205(80)90620-7.
10
Binding of vasoactive intestinal peptide and its stimulation of adenylate cyclase through two classes of receptors in rat liver membranes. Effects of 12 secretin analogues and 2 secretin fragments.血管活性肠肽的结合及其通过大鼠肝细胞膜上两类受体对腺苷酸环化酶的刺激作用。12种促胰液素类似物和2种促胰液素片段的作用。
Biochim Biophys Acta. 1981 Nov 18;678(1):83-90. doi: 10.1016/0304-4165(81)90050-7.

引用本文的文献

1
Different effects of visual deprivation on vasoactive intestinal polypeptide (VIP)-containing cells in the retinas of juvenile and adult rats.视觉剥夺对幼年和成年大鼠视网膜中含血管活性肠肽(VIP)细胞的不同影响。
Exp Brain Res. 1996 Oct;111(3):345-55. doi: 10.1007/BF00228724.
2
Somatostatin and VIP neurons in the retina of different species.不同物种视网膜中的生长抑素和血管活性肠肽神经元。
Histochemistry. 1982;76(2):137-52. doi: 10.1007/BF00501917.