Nickolson V J
Eur J Pharmacol. 1981 Jun 10;72(1):45-56. doi: 10.1016/0014-2999(81)90295-8.
Rat open field behaviour was measured in a TV-based, automated system. Habituation was evident in saline-treated rats. Most variables measured declined over a 10 min period. Apomorphine affected rat open-field behaviour bimodally, i.e. low doses of apomorphine (0.02-0.08 mg/kg, s.c.) decreased most aspects of rat open-field behaviour, whereas at higher doses (0.2 and 0.5 mg/kg, s.c.) various aspects of open-field behaviour were stimulated. Rearing and average speed, however, were monotonically depressed. Amphetamine (1 and 2 mg/kg) stimulated most aspects of rats open-field behaviour, including rearing. Speed was not affected by amphetamine. Habituation was more pronounced after low doses of apomorphine than after saline treatment and was absent after high doses of apomorphine and after amphetamine. The results represent a detailed analysis of apomorphine and amphetamine effects on rat open-field behaviour and show that the distinct components of this behaviour are affected differentially.
大鼠旷场行为在基于电视的自动化系统中进行测量。生理盐水处理的大鼠出现了习惯化现象。在10分钟的时间段内，所测量的大多数变量都有所下降。阿扑吗啡对大鼠旷场行为有双峰效应，即低剂量的阿扑吗啡（0.02 - 0.08毫克/千克，皮下注射）会降低大鼠旷场行为的大多数方面，而高剂量（0.2和0.5毫克/千克，皮下注射）则会刺激旷场行为的各个方面。然而，竖毛和平均速度则持续降低。苯丙胺（1和2毫克/千克）刺激了大鼠旷场行为的大多数方面，包括竖毛。速度不受苯丙胺影响。低剂量阿扑吗啡后的习惯化比生理盐水处理后更明显，高剂量阿扑吗啡和苯丙胺处理后则不存在习惯化现象。这些结果代表了对阿扑吗啡和苯丙胺对大鼠旷场行为影响的详细分析，并表明该行为的不同组成部分受到不同程度影响。
