米安色林、其主要代谢产物及6-氮杂米安色林的比较药理学 - Suppr

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超能文献

Comparative pharmacology of mianserin, its main metabolites and 6-azamianserin.

作者信息

Nickolson V J, Wieringa J H, van Delft A M

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1982 Apr;319(1):48-55. doi: 10.1007/BF00491478.

DOI:10.1007/BF00491478

PMID:6287300

Abstract

摘要

相似文献

Comparative pharmacology of mianserin, its main metabolites and 6-azamianserin.米安色林、其主要代谢产物及6-氮杂米安色林的比较药理学

Naunyn Schmiedebergs Arch Pharmacol. 1982 Apr;319(1):48-55. doi: 10.1007/BF00491478.

Mianserin: direct activation of brain norepinephrine neurons by blocking alpha 2-receptors.米安色林：通过阻断α2受体直接激活脑内去甲肾上腺素能神经元。

Commun Psychopharmacol. 1980;4(3):233-9.

Blockade of presynaptic alpha-receptors and of amine uptake in the rat brain by the antidepressant mianserine.抗抑郁药米安色林对大鼠脑内突触前α受体的阻断及胺摄取的影响

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):31-7. doi: 10.1007/BF00505077.

On the mode of action of mianserin.关于米安色林的作用方式。

Adv Biochem Psychopharmacol. 1982;31:301-19.

Differential blockade by (-)mianserin of the alpha 2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes.（-）米安色林对介导大鼠脑突触体去甲肾上腺素和5-羟色胺释放抑制的α2-肾上腺素能受体的差异性阻断作用。

Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar;322(2):180-2. doi: 10.1007/BF00512394.

Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?米安色林对映体及代谢产物的肾上腺素能受体相互作用：它们与抗抑郁作用有关吗？

Acta Psychiatr Scand Suppl. 1985;320:1-9. doi: 10.1111/j.1600-0447.1985.tb08068.x.

Supersensitivity of central noradrenergic presynaptic autoreceptors following chronic treatment with the antidepressant mianserin.抗抑郁药米安色林长期治疗后中枢去甲肾上腺素能突触前自身受体的超敏反应

Eur J Pharmacol. 1981 Mar 26;70(3):425-6. doi: 10.1016/0014-2999(81)90176-x.

Chronic effects of mianserin on noradrenaline metabolism in the rat brain: evidence for a pre-synaptic alpha-adrenolytic action in vivo.米安色林对大鼠脑内去甲肾上腺素代谢的慢性影响：体内突触前α-肾上腺素能阻滞作用的证据。

Psychopharmacology (Berl). 1979 Sep;64(3):329-32. doi: 10.1007/BF00427519.

The effect of a tetracyclic antidepressant compound, Org GB94, on the turnover of biogenic amines in rat brain.四环抗抑郁化合物Org GB94对大鼠脑内生物胺代谢周转的影响。

Biochem Pharmacol. 1976 Nov 15;25(22):2455-60. doi: 10.1016/0006-2952(76)90447-0.

Mianserin, an antidepressant with a unique neuropharmacological profile.米安色林，一种具有独特神经药理学特性的抗抑郁药。

Acta Psychiatr Belg. 1978 Sep-Oct;78(5):770-80.

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Metabolic -Dealkylation and -Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors.代谢脱烷基化和氧化在阐明各种受体作用的药物中氨基烷基部分的作用。

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Antidepressant drugs with differing pharmacological actions decrease activity of locus coeruleus neurons.具有不同药理作用的抗抑郁药可降低蓝斑核神经元的活性。

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Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice.新型西格玛（σ）受体激动剂在小鼠中产生抗抑郁样效应。

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[N-methyl-11C]Mirtazapine for positron emission tomography neuroimaging of antidepressant actions in humans.

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Pharmaco-EEG study of 6-azamianserin (ORG 3770): dissociation of EEG and pharmacologic predictors of antidepressant activity.6-氮杂色胺（ORG 3770）的药物脑电图研究：脑电图与抗抑郁活性药理学预测指标的分离

Psychopharmacology (Berl). 1982;78(1):44-8. doi: 10.1007/BF00470586.

Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar;322(2):180-2. doi: 10.1007/BF00512394.

Evidence that mCPP may have behavioural effects mediated by central 5-HT1C receptors.有证据表明，mCPP可能具有由中枢5-羟色胺1C受体介导的行为效应。

Br J Pharmacol. 1988 May;94(1):137-47. doi: 10.1111/j.1476-5381.1988.tb11508.x.

Effect of the antidepressant Org 3770 on human sleep.

Eur J Clin Pharmacol. 1990;38(6):551-4. doi: 10.1007/BF00278580.

Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity.米安色林及其对映体和代谢产物在抗抑郁活性行为筛选中的效果比较。

Psychopharmacology (Berl). 1991;105(4):453-8. doi: 10.1007/BF02244363.

5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model.

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本文引用的文献

Clonidine-induced diuresis in the rat: evidence for a renal site of action.可乐定对大鼠的利尿作用：作用于肾脏部位的证据。

J Pharmacol Exp Ther. 1980 Sep;214(3):608-13.

Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites.

Acta Pharmacol Toxicol (Copenh). 1980 Jul;47(1):53-7. doi: 10.1111/j.1600-0773.1980.tb02025.x.

Detailed analysis of the effects of apomorphine and d-amphetamine on spontaneous locomotor behaviour of rats as measured in a TV-based, automated open-field system.在基于电视的自动化旷场系统中，对阿扑吗啡和右旋苯丙胺对大鼠自发运动行为的影响进行详细分析。

Eur J Pharmacol. 1981 Jun 10;72(1):45-56. doi: 10.1016/0014-2999(81)90295-8.

Functional evidence for subsensitivity of noradrenergic alpha 2 receptors after chronic desipramine treatment.

Life Sci. 1980 Nov 17;27(20):1863-7. doi: 10.1016/0024-3205(80)90431-2.

Tricyclic antidepressant drug interactions with histamine and alpha-adrenergic receptors.三环类抗抑郁药与组胺及α-肾上腺素能受体的相互作用。

Pharmakopsychiatr Neuropsychopharmakol. 1980 Mar;13(2):62-7. doi: 10.1055/s-2007-1019614.

Antidepressant drug action and presynaptic alpha-receptors.

Mayo Clin Proc. 1980 Sep;55(9):567-72.

Alpha-adrenergic receptor subtypes.α-肾上腺素能受体亚型

N Engl J Med. 1980 Jun 19;302(25):1390-6. doi: 10.1056/NEJM198006193022504.

Presynaptic alpha-block and inhibition of noradrenaline and 5-hydroxytryptamine reuptake by a series of compounds related to mianserin.

J Pharm Pharmacol. 1981 Dec;33(12):760-6. doi: 10.1111/j.2042-7158.1981.tb13927.x.

Differences in presynaptic alpha-blockade, noradrenaline uptake inhibition, and potential antidepressant activity between (+)- and (-)mianserin.（+）-米安色林与（-）-米安色林在突触前α-阻断、去甲肾上腺素摄取抑制及潜在抗抑郁活性方面的差异。

Psychopharmacology (Berl). 1981;74(2):137-42. doi: 10.1007/BF00432680.

The tetracyclic antidepressant mianserin: evaluation of its blockade of presynaptic alpha-adrenoceptors in a self-stimulation model using clonidine.四环类抗抑郁药米安色林：在使用可乐定的自我刺激模型中对其对突触前α-肾上腺素能受体阻断作用的评估。

Eur J Pharmacol. 1981 Mar 5;70(1):59-63. doi: 10.1016/0014-2999(81)90432-5.

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