Matsubara Y, Shirakabe A, Suzuki Y, Chiba T
Jikken Dobutsu. 1981 Jan;30(1):15-20. doi: 10.1538/expanim1978.30.1_15.
The effects of artificial oligemic anemia on dams and their fetuses were investigated in pregnant rats. Animals divided into ten groups of four to six each were bled from the jugular vein at various stages of gestation. Hematological examination was performed on day 20 of gestation, then dams were sacrificed. Depression of maternal weight gain, decrease of food intake and increase of water intake were recognized in all the bled groups. These changes were more conspicuous in the groups venipunctured at early stages of organogenesis. At autopsy, there was no evidence of anemia in any of the groups bled before day 10 of pregnancy whereas the does bled after day 12 were found anemic. In term fetuses from these anemic mothers, however, no adverse findings suggestive of feto-toxicity and teratogenicity were noted.
在怀孕大鼠中研究了人工造成的低血容量性贫血对母鼠及其胎儿的影响。将动物分成十组，每组四至六只，在妊娠的不同阶段从颈静脉放血。在妊娠第20天进行血液学检查，然后处死母鼠。所有放血组均出现母鼠体重增加受抑制、食物摄入量减少和饮水量增加的情况。这些变化在器官形成早期进行静脉穿刺的组中更为明显。尸检时，在妊娠第10天之前放血的任何组中均未发现贫血迹象，而在第12天之后放血的母鼠则出现贫血。然而，在这些贫血母亲的足月胎儿中，未观察到提示胎儿毒性和致畸性的不良发现。
