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[在规定疗程的磺胺二甲嘧啶和磺胺间甲氧嘧啶联合紫外线照射期间白鼠肾上腺功能状态的若干指标]

[Several indices of the functional state of the adrenals of white rats during a prescribed course of sulfadimezine and sulfamonomethoxine combined with UV-irradiation].

作者信息

Matveeva S A

出版信息

Farmakol Toksikol. 1981 Jan-Feb;44(1):107-9.

PMID:7262292
Abstract

Chronic treatment with sulfadimesin or sulfamonomethoxin combined with UV irradiation leads to potentiation of adrenocortical function. As the observation period increases, the weight ratios of the adrenals grow which is accompanied by the decreased content of ascorbic acid in them and by the reduced weight ratios of the goiter and spleen. Combined chronic use of sulfanilamides and UV irradiation results in an increase of the total acetylating capacity of the body, especially in the day time.

摘要

用磺胺二甲嘧啶或磺胺间甲氧嘧啶进行长期治疗并结合紫外线照射会导致肾上腺皮质功能增强。随着观察期延长,肾上腺的重量比增加,同时肾上腺中抗坏血酸含量降低,甲状腺和脾脏的重量比减小。磺胺类药物与紫外线照射联合长期使用会使机体的总乙酰化能力增加,尤其是在白天。

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1
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