Avakumov V M, Kovler M A
Farmakol Toksikol. 1981 Jan-Feb;44(1):30-4.
Experiments on albino mice and rats have shown that pantogam, a derivative of pantothenic acid, potentiates the hypnotic effects of hexobarbital and barbital and enhances the effect of subthreshold doses of hexobarbital. The drug inhibits the amphetamine action in the amphetamine hyperaction test without affecting hexobarbital and amphetamine metabolism, or without increasing the blood-brain barrier permeability for these compounds and barbital. Pantogam does not influence the intensity of ethylmorphine N-demethylation in liver homogenates and the content of cytochrome P 450 and b5 in liver microsomes.
对白化病小鼠和大鼠的实验表明，泛硫乙胺（泛酸的一种衍生物）可增强己巴比妥和巴比妥的催眠作用，并增强阈下剂量己巴比妥的效果。在苯丙胺多动试验中，该药物可抑制苯丙胺的作用，而不影响己巴比妥和苯丙胺的代谢，也不会增加这些化合物和巴比妥的血脑屏障通透性。泛硫乙胺不影响肝匀浆中乙基吗啡N-去甲基化的强度以及肝微粒体中细胞色素P 450和b5的含量。
