Efimov V S, Rozkin M Ia, Poberiĭ I A, Lindner D P
Farmakol Toksikol. 1981 Jan-Feb;44(1):80-5.
The paper concerns the effect of heparin and its antagonists, protamine and 2,5-ionen, on mast cell population from the standpoint of its potential action on blood coagulation. It has been established that intravenous administration of heparin is accompanied by its deposition in mast cells, that gives rise to rapid excretion of the anticoagulant from the blood flow. It has been also shown that protamine sulfate and 2,5-ionen produce degranulation of mast cells, but the synthetic polycation is superior over protamine sulfate in binding heparin of extracellular granules. Retaining of the increased saturation of mast cells with heparin on neutralization of the anticoagulant effect with protamine forms a structural basis for the origination of recurrent heparinemia. Study of blood coagulation has shown that 2,5-ionen is a more efficacious heparin antagonist than protamine sulfate.
本文从肝素及其拮抗剂鱼精蛋白和2,5-亚乙基己二醇对血液凝固的潜在作用角度，探讨了它们对肥大细胞群体的影响。已经确定，静脉注射肝素会伴随着其在肥大细胞中的沉积，这会导致抗凝剂从血流中快速排出。还表明硫酸鱼精蛋白和2,5-亚乙基己二醇会使肥大细胞脱颗粒，但合成聚阳离子在结合细胞外颗粒中的肝素方面优于硫酸鱼精蛋白。用鱼精蛋白中和抗凝作用时，肥大细胞中肝素饱和度增加的持续存在为复发性肝素血症的发生形成了结构基础。血液凝固研究表明，2,5-亚乙基己二醇是比硫酸鱼精蛋白更有效的肝素拮抗剂。
