[Effect of the quaternary ammonium salts of the monodisperse oligomers of conidine on a mast cell population].

The authors studied the effect of mast cell population of a new group of synthetic heparin antagonists--quaternary ammonium salts of monodispersed conidine oligomers of different molecular masses and the effect of conidine monomer under the conditions of heparin neutralization and without preliminary administration of the anticoagulant. The conidine monomer was discovered to be a solitary compound that produced a significant shift of the mast cell population toward light forms. Administration of both conidine monomer and oligomers after the neutralization doses of heparin did not disturb the equilibrium of the mast cell population. At the same time no relationship was established between the changes in the status of labrocytes and molecular mass of conidine derivatives. Degranulation of mast cells remained significantly unchanged in all the series of experiments.