草地早熟禾花粉两种不同抗原的变应原关系。

Allergenic relationships of two different antigens of Kentucky bluegrass pollen.

作者信息

Chakrabarty S, Ekramoddoullah A K, Kisil F T, Sehon A H

出版信息

Int Arch Allergy Appl Immunol. 1981;66(1):13-20. doi: 10.1159/000232794.

Abstract

Two purified allergens, allergen C and KBG-1, isolated from Kentucky bluegrass (KBG) pollen, were found to be antigenically distinct with respect to rabbit precipitating antisera produced separately to each allergen. On the other hand, allergen C and KBG-1 appeared to be allergenically identical in terms of the specificities evaluated with murine reaginic antisera produced to each of these allergens; whereas they appeared to be only partially identical when evaluated with respect to the IgE antibodies present in a pool of human sera from individuals allergic to KBG pollen. Therefore, not all of the allergenic determinants recognized by the human IgE antibodies were detected by the murine reaginic antisera. This study serves to emphasize that for a meaningful evaluation of allergenic specificities any antisera prepared in animals and intended for the standardization of allergens must recognize allergenic specificities which are similar or identical to those to which the human IgE antibodies are directed.

摘要

从草地早熟禾（KBG）花粉中分离出的两种纯化过敏原，过敏原C和KBG - 1，就分别针对每种过敏原产生的兔沉淀抗血清而言，它们在抗原性上是不同的。另一方面，就用针对这些过敏原各自产生的鼠反应素抗血清评估的特异性而言，过敏原C和KBG - 1在变应原性上似乎是相同的；而当用来自对KBG花粉过敏个体的人血清池中的IgE抗体进行评估时，它们似乎只是部分相同。因此，鼠反应素抗血清并未检测到人类IgE抗体识别的所有变应原决定簇。这项研究旨在强调，为了对变应原特异性进行有意义的评估，任何在动物体内制备并用于变应原标准化的抗血清都必须识别与人类IgE抗体所针对的变应原特异性相似或相同的变应原特异性。