Gunst S J, Mitzner W
J Appl Physiol Respir Environ Exerc Physiol. 1981 Jun;50(6):1236-47. doi: 10.1152/jappl.1981.50.6.1236.
Airways of 2-5 mm in diameter were dissected from fresh dog lungs and mounted in a tissue bath so that they could be inflated and deflated with air. Length was held constant, and pressure and volume were monitored on an X-Y recorder. Pressure-volume curves were obtained for each airway at several difference degrees of constriction, by varying the concentration of acetylcholine (ACh) in the bath. Properties of the tissue were analyzed cy cycling airways at different speeds and by inflating them to various pressures. Circumferential length-tension curves were calculated from the inflation limbs of pressure-volume curves obtained by slow cycling (90 s for a complete cycle between -10 and 40 cmH2O). Administration of a series of increasing concentrations of ACh resulted in length-tension curves that were displaced to shorter lengths but not greatly altered in slope. These results suggest that slow inflation of the bronchus stretched only passive elements in series with a contractile element which shortened to the length determined by the concentration of ACh present.
从新鲜的狗肺中解剖出直径为2 - 5毫米的气道，并将其安装在组织浴中，以便可以用空气进行充气和放气。长度保持恒定，压力和体积在X - Y记录仪上进行监测。通过改变浴中乙酰胆碱（ACh）的浓度，在几种不同程度的收缩情况下获得每个气道的压力 - 体积曲线。通过以不同速度循环气道并将它们充气到不同压力来分析组织的特性。根据通过缓慢循环（在 - 10和40 cmH₂O之间完整循环90秒）获得的压力 - 体积曲线的充气部分计算周向长度 - 张力曲线。施用一系列递增浓度的ACh导致长度 - 张力曲线向更短的长度位移，但斜率没有很大改变。这些结果表明，支气管的缓慢充气仅拉伸了与收缩元件串联的被动元件，该收缩元件缩短到由存在的ACh浓度决定的长度。
