Kurnick J E
Chest. 1977 Dec;72(6):798-9. doi: 10.1378/chest.72.6.798.
A 26-year-old white man with stage 4-B Hodgkin's disease resistant to conventional chemotherapy obtained complete remission with administration of bleomycin. Maintenance of this remission required continued therapy with bleomycin. The patient received a total of 2,700 units of bleomycin over a 51-month period without signs or symptoms of pulmonary toxicity. Serial studies of pulmonary function have shown a stable forced vital capacity and minimally decreased total lung volume and pulmonary diffusing capacity. This case demonstrates the ability of a patient to tolerate massive cumulative doses ob bleomycin over a protracted period without severe loss of pulmonary function.
一名26岁的白人男性，患有4 - B期霍奇金病，对传统化疗耐药，使用博来霉素后获得完全缓解。维持这种缓解需要持续使用博来霉素治疗。该患者在51个月的时间里共接受了2700单位的博来霉素，没有出现肺部毒性的体征或症状。一系列肺功能研究显示，用力肺活量稳定，肺总量和肺弥散量略有下降。该病例表明，患者能够在较长时间内耐受大量累积剂量的博来霉素，而不会出现严重的肺功能丧失。
