Sale S R, Roach D E, Zeiss C R, Patterson R
J Allergy Clin Immunol. 1981 Sep;68(3):188-93. doi: 10.1016/0091-6749(81)90182-2.
Twenty workers exposed to trimellitic anhydride (TMA) powder were evaluated to correlate respiratory symptoms with total antibody activity against trimellityl human serum albumin (TM-HSA). Further, specific IgG, IgA, and IgE against TM-HSA were compared to total specific antibody levels against that antigen. The workers were categorized clinically as having either the late respiratory systemic syndrome (LRSS), immediate rhinitis and asthma, or an irritant reaction. There were no histories compatible with the pulmonary disease--anemia syndrome. Total antibody and IgG antibody activity to TM-HSA correlated well (R8 = 0.75, p less than 0.05). Total antibody activity was found in almost all TMA-exposed workers, it did not discriminate the symptomatic workers from asymptomatic workers as well as did the IgG or total antibody determinations. IgE antibody activity against TM-HSA was elevated in one worker with immediate-type asthma. Previous studies correlated symptoms caused by TMA inhalation with antibody activity. This study indicates that clinical assessment plus total antibody determination or IgG antibody and IgE antibody determination should establish a means of diagnosis of the presence or absence of immunologic respiratory disease caused by TMA powder.
对20名接触偏苯三酸酐（TMA）粉末的工人进行了评估，以将呼吸道症状与针对偏苯三酰人血清白蛋白（TM-HSA）的总抗体活性相关联。此外，将针对TM-HSA的特异性IgG、IgA和IgE与针对该抗原的总特异性抗体水平进行了比较。这些工人在临床上被分类为患有晚期呼吸系统综合征（LRSS）、速发型鼻炎和哮喘或刺激性反应。没有与肺部疾病-贫血综合征相符的病史。针对TM-HSA的总抗体和IgG抗体活性相关性良好（R8 = 0.75，p < 0.05）。几乎所有接触TMA的工人都发现了总抗体活性，但它在区分有症状工人和无症状工人方面不如IgG或总抗体测定有效。一名患有速发型哮喘的工人中，针对TM-HSA的IgE抗体活性升高。先前的研究将吸入TMA引起的症状与抗体活性相关联。本研究表明，临床评估加上总抗体测定或IgG抗体和IgE抗体测定应建立一种诊断由TMA粉末引起的免疫性呼吸道疾病是否存在的方法。
