低分子量化学物质、超敏反应及直接毒性：酸酐类物质
Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides.
作者信息
Venables K M
机构信息
Department of Occupational Medicine, National Heart and Lung Institute, Brompton Hospital, London, UK.
出版信息
Br J Ind Med. 1989 Apr;46(4):222-32. doi: 10.1136/oem.46.4.222.
Abstract
The acid anhydrides are a group of reactive chemicals used widely in alkyd and epoxy resins. The major hazards to health are mucosal and skin irritation and sensitisation of the respiratory tract. Most occupational asthma caused by acid anhydrides appears to be immunologically mediated. Immunological mechanisms have been proposed to explain an influenza-like syndrome and pulmonary haemorrhage, but direct toxicity may also be important in the aetiology of these conditions.
摘要
酸酐是一类广泛应用于醇酸树脂和环氧树脂的活性化学品。对健康的主要危害是黏膜和皮肤刺激以及呼吸道致敏。大多数由酸酐引起的职业性哮喘似乎是由免疫介导的。已提出免疫机制来解释类似流感的综合征和肺出血，但直接毒性在这些病症的病因中可能也很重要。
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