Fuchs A R, Cubile L, Dawood M Y
J Endocrinol. 1981 Aug;90(2):245-53. doi: 10.1677/joe.0.0900245.
The effects of mating on plasma levels of oxytocin and prolactin in male and females rabbits have been investigated. Blood was collected through indwelling cardiac catheters at intervals of 1, 2, 4, 6, 12, 24, 36 and 60 min after mating. In female rabbits additional samples were taken 5h after mating, as well as daily during the ensuing pregnancy or pseudopregnancy. They were also fitted with intrauterine balloons for recording uterine activity. Copulation induced a rapid, transient rise in plasma oxytocin in female rabbits at the same time as a fall in plasma prolactin. Mating or sexual excitement had no significant effect on plasma concentrations of oxytocin or prolactin in bucks. Relatively large fluctuations of plasma oxytocin were seen in male rabbits under normal conditions and after mating, suggesting episodic release of oxytocin in a random fashion. The uterine recordings indicated that, in spite of the modest release of oxytocin, a strong sympathetic adrenal activation occurred in response to mating and this provided the overriding influence on uterine activity. During pregnancy plasma levels of prolactin rose significantly on day 4, and remained raised throughout most of gestation. Plasma prolactin fluctuated widely during the first half of pregnancy but the mean levels were higher than those found during the second half of gestation. When pseudopregnancy was induced with injection of an ovulating dose of LH, plasma prolactin rose in a similar manner as during early gestation or mating-induced pseudopregnancy. Thus, in contrast to rats, stimuli associated with mating have no direct influence on the subsequent release of prolactin in rabbits. The secretion of prolactin during gestation seems to be controlled entirely by ovarian steroids, probably progesterone.
对雌雄兔交配后血浆中催产素和催乳素水平的影响进行了研究。交配后每隔1、2、4、6、12、24、36和60分钟通过留置心导管采集血液。对于雌兔，在交配后5小时以及随后怀孕或假孕期间每天额外取样。它们还被植入子宫内气囊以记录子宫活动。交配导致雌兔血浆催产素迅速短暂升高，同时血浆催乳素下降。交配或性兴奋对公兔血浆中催产素或催乳素的浓度没有显著影响。在正常条件下和交配后，雄兔血浆催产素出现相对较大的波动，表明催产素以随机方式呈间歇性释放。子宫记录表明，尽管催产素释放量不大，但交配会引发强烈的交感肾上腺激活，这对子宫活动产生了主要影响。在怀孕期间，催乳素水平在第4天显著升高，并在妊娠的大部分时间内保持升高。在怀孕的前半段，血浆催乳素波动很大，但平均水平高于妊娠后半段。当注射促排卵剂量的促黄体生成素诱导假孕时，血浆催乳素的升高方式与早期妊娠或交配诱导的假孕相似。因此，与大鼠不同，交配相关刺激对兔随后催乳素的释放没有直接影响。妊娠期间催乳素的分泌似乎完全由卵巢类固醇（可能是孕酮）控制。
