Eslinger P J, Damasio A R
J Neurol Neurosurg Psychiatry. 1981 May;44(5):377-81. doi: 10.1136/jnnp.44.5.377.
The age and gender of a series of patients with different types of aphasia were analysed. Regardless of gender, patients with Broca and conduction aphasias were significantly younger than those with Wernicke and global aphasias. Considering the established cerebral localisation of each of those aphasia types, it appears that, with age, stroke in the territory of the middle cerebral artery will tend to either shift posteriorly (producing Wernicke aphasia) or occupy most of the middle cerebral artery territory (producing global aphasia). But in the absence of concurrent verification of the locus of lesion in each of the cases in our sample, a possible alternative hypothesis must be entertained: that there might be age-related changes in the neurophysiological mechanism subserving language, such that some types of aphasia would tend to be more prevalent with age, regardless of lesion location.
对一系列不同类型失语症患者的年龄和性别进行了分析。无论性别如何，布罗卡失语症和传导性失语症患者的年龄显著低于韦尼克失语症和完全性失语症患者。考虑到每种失语症类型既定的脑定位，随着年龄增长，大脑中动脉区域的中风似乎要么向后移位（导致韦尼克失语症），要么占据大脑中动脉的大部分区域（导致完全性失语症）。但由于我们样本中的每个病例均未同时对病变部位进行验证，因此必须考虑另一种可能的假设：即语言的神经生理机制可能存在与年龄相关的变化，因此某些类型的失语症可能会随着年龄增长而更普遍，而与病变位置无关。
