溴隐亭治疗帕金森病：心血管效应研究
Bromocriptine in Parkinson's disease: a study of cardiovascular effects.
作者信息
Quinn N, Illas A, Lhermitte F, Agid Y
出版信息
J Neurol Neurosurg Psychiatry. 1981 May;44(5):426-9. doi: 10.1136/jnnp.44.5.426.
Abstract
Blood pressure and pulse rate were studied in 20 Parkinsonian patients on no treatment, and during treatment with bromocriptine (mean dosage 148 mg/day) as the sole anti-Parkinsonian therapy. The drug was shown to reduce erect systolic and diastolic and supine systolic blood pressure and to increase erect pulse rate, in a predictable dose-dependent manner. The occurrence of episodes of significant postural hypotension was less predictable and was a transitory phenomenon in all patients. Peripheral dopamine receptor blockade with domperidone did not alter the findings, suggesting that the principal mechanism for these cardiovascular effects is a central dopaminergic one.
摘要
对20例未接受治疗的帕金森病患者以及仅接受溴隐亭（平均剂量148毫克/天）作为抗帕金森病单一疗法治疗期间的血压和脉搏率进行了研究。结果显示，该药物可降低直立位收缩压和舒张压以及仰卧位收缩压，并以可预测的剂量依赖性方式增加直立位脉搏率。严重体位性低血压发作的发生较难预测，且在所有患者中均为一过性现象。使用多潘立酮进行外周多巴胺受体阻断并未改变这些结果，提示这些心血管效应的主要机制是中枢多巴胺能机制。
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