生物流体中吲达帕胺的半自动测定法。
Semiautomated assay for indapamide in biological fluids.
作者信息
Grebow P E, Treitman J A, Yeung A K, Johnston M M
出版信息
J Pharm Sci. 1981 Mar;70(3):306-8. doi: 10.1002/jps.2600700321.
A sensitive fluorescence procedure for the determination of indapamide in plasma and whole blood was developed. The procedure requires preextraction of the biological sample followed by continuous-flow analysis. The assay is sensitive to indapamide levels of 25 ng/ml in plasma and blood. A linear response from 25 to 200 ng/ml is observed. The procedure also can be used to measure urinary levels of indapamide. The assay has been used to obtain whole blood and plasma level curves from subjects receiving 2.5 mg of indapamide.
建立了一种灵敏的荧光法测定血浆和全血中的吲达帕胺。该方法需要对生物样品进行预萃取，然后进行连续流动分析。该测定法对血浆和血液中25 ng/ml的吲达帕胺水平敏感。在25至200 ng/ml范围内观察到线性响应。该方法还可用于测量尿液中吲达帕胺的水平。该测定法已用于获得接受2.5 mg吲达帕胺受试者的全血和血浆水平曲线。
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