Batist G, Andrews J L
JAMA. 1981 Sep 25;246(13):1449-53.
Pulmonary toxicity caused by antineoplastic drugs is becoming a more frequently recognized entity, and the number of drugs known or suspected of causing this disease is steadily increasing. In general, the initial clinical appearance includes both constitutional signs of malaise and fever, as well as pulmonary complaints. Some clinical signs may suggest a particular drug as the cause. The pathological condition also is generally nonspecific, but some clues may be present histologically that help define the causal agent. This is a review of the antineoplastic drugs that are associated with pulmonary toxicity. Clinical, laboratory, and pathological data are presented as useful information for practicing physicians. Although therapeutic maneuvers are limited, these are discussed with regard to each drug.
抗肿瘤药物引起的肺部毒性正日益成为一个被更频繁认识到的问题，已知或怀疑会导致这种疾病的药物数量在稳步增加。一般来说，最初的临床症状包括全身不适和发热的体征，以及肺部症状。一些临床体征可能提示某种特定药物为病因。病理状况通常也不具有特异性，但组织学上可能存在一些线索有助于确定致病因素。本文综述了与肺部毒性相关的抗肿瘤药物。文中呈现了临床、实验室和病理数据，为执业医生提供有用信息。尽管治疗手段有限，但针对每种药物都进行了讨论。
