Nakamura K, Nishiyama S, Takata T, Suzuki E, Sugiura Y, Kobayashi T
Sangyo Igaku. 1981 Mar;23(2):141-5. doi: 10.1539/joh1959.23.141.
The superimposed effects of oral zinc administration on cadmium-induced ultrastructural changes in rat livers were studied. Twenty female rats were divided into 4 groups. To the diet for group I was added 200 ppm Cd for daily about 10 g diet, to that for group II 200 ppm of Zn and that for group III 200 ppm of Cd and Zn each. The group IV was the control. All of the four groups was sacrificed after 9 months of administration. In addition to examine the liver by an electron-microscope, Cd concentration in the liver was analyzed by atomic absorption spectrophotometry. The Cd contents in the livers of group III were significantly reduced compared with those of group I. Apparent ultrastructural changes; i.e., deterioration of rough endoplasmic reticula, losses of glycogen particles, and proliferation of smooth endoplasmic reticula, were observed in the livers of group I. Meanwhile, these changes were significantly mild in those of group III. From these results, it is suggested that Cd inhibits protein synthesis and glycogen metabolism in the liver and that Zn partly protects the liver from Cd-induced ultrastructural changes.
研究了口服锌对镉诱导的大鼠肝脏超微结构变化的叠加作用。将20只雌性大鼠分为4组。在第一组大鼠的日粮中添加200 ppm镉，每日约10克日粮；在第二组日粮中添加200 ppm锌；在第三组日粮中同时添加200 ppm镉和锌。第四组为对照组。给药9个月后处死所有4组大鼠。除了用电子显微镜检查肝脏外，还用原子吸收分光光度法分析肝脏中的镉浓度。与第一组相比，第三组肝脏中的镉含量显著降低。在第一组大鼠的肝脏中观察到明显的超微结构变化，即粗面内质网退化、糖原颗粒丢失和平滑内质网增生。同时，第三组大鼠肝脏中的这些变化明显较轻。从这些结果可以看出，镉抑制肝脏中的蛋白质合成和糖原代谢，而锌可以部分保护肝脏免受镉诱导的超微结构变化的影响。
