Someya S, Mizuhara H, Murata R, Kurokawa M
Jpn J Med Sci Biol. 1981 Feb;34(1):21-35.
Immune response of man to tetanus and diphtheria-tetanus combined toxoids with different compositions was investigated, with special reference to the long-term immunity. Adsorbed tetanus toxoid with a potency of about 25 IU per human dose endowed a long-lasting immunity sufficient to prevent tetanus to the vaccines of various age groups, when administered in two doses, followed by a booster injection. Two doses of adsorbed diphtheria-tetanus combined toxoid with potencies of about 20 IU per dose for both components were sufficient to give immunity in infants against diphtheria and tetanus. However, a booster injection should be given within a year to endow a long-lasting immunity. In the case of booster immunization of children with a complete history of immunization against diphtheria and tetanus, a potent long-term immunity was endowed by a single injection of diphtheria-tetanus combined toxoid (plain) with 1 and 3.5 IU per dose, for diphtheria and tetanus components, respectively.
研究了人对不同成分的破伤风类毒素以及白喉-破伤风联合类毒素的免疫反应，特别关注长期免疫情况。每剂含约25国际单位效力的吸附破伤风类毒素，分两剂接种并随后进行加强注射时，能赋予各年龄组疫苗接种者足以预防破伤风的持久免疫力。两剂各成分效力约为每剂20国际单位的吸附白喉-破伤风联合类毒素足以使婴儿获得对白喉和破伤风的免疫力。然而，应在一年内进行加强注射以赋予持久免疫力。对于有完整白喉和破伤风免疫史的儿童进行加强免疫时，分别每剂含1国际单位和3.5国际单位白喉和破伤风成分的一剂（普通）白喉-破伤风联合类毒素能赋予有效的长期免疫力。
