Tillman P, Carson S N, Talken L
Lab Anim Sci. 1981 Jun;31(3):263-7.
Various clotting parameters (prothrombin time, activated coagulation time, activated partial thromboplastin time, platelet counts, and platelet aggregation) were obtained from unanesthetized sheep and from sheep at various times during 5 hours of vascular surgery. The values obtained were not influenced by anesthesia and surgery and were consistent between sheep. Ovine platelets were less prone to aggregate in the presence of collagen, epinephrine, and ristocetin than those of man. Platelet aggregation induced by adenosine diphosphate was similar to that seen in man. Based on these parameters, the sheep would seem to be a reasonable model for experimental vascular surgery when results are to be applied to man.
从未麻醉的绵羊以及在血管手术5小时期间不同时间点的绵羊身上获取了各种凝血参数（凝血酶原时间、活化凝血时间、活化部分凝血活酶时间、血小板计数和血小板聚集）。所获得的值不受麻醉和手术的影响，并且在绵羊之间是一致的。与人类血小板相比，绵羊血小板在胶原蛋白、肾上腺素和瑞斯托菌素存在的情况下较不易聚集。由二磷酸腺苷诱导的血小板聚集与人类相似。基于这些参数，当将结果应用于人类时，绵羊似乎是实验性血管手术的一个合理模型。
