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The PGE1, infused into the renal artery of the dog, increased RPF, Sodium and Potassium excretion rate and UV; it diminished the EPAH and FF but did not alter GFR and PRA. 2. The indomethacin, injected IV, in an other group of animals, decreased RPF, GFR, Sodium and Potassium excretion rate and PRA, and it increased the EPAH and FF. The administration of the PGE1, inversed the results obtained by indomethacin except those of PRA. 3. The infusion of the PGF1a, in other groups of dogs, did not alter either before or after the administration of indomethacin the parameters measured. 4. It was suggested that 1) neither the PGE1 nor the PGF1a stimulated renin synthesis, in the conditions that our experiments took place. The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.

将前列腺素E1注入狗的肾动脉，可增加肾血浆流量、钠和钾排泄率以及尿流量；它降低了对氨基马尿酸清除率和滤过分数，但未改变肾小球滤过率和血浆肾素活性。2. 在另一组动物中静脉注射消炎痛，可降低肾血浆流量、肾小球滤过率、钠和钾排泄率以及血浆肾素活性，并增加对氨基马尿酸清除率和滤过分数。给予前列腺素E1可逆转消炎痛所产生的结果，但血浆肾素活性的结果除外。3. 在其他几组狗中，注入前列腺素F1α，无论在给予消炎痛之前还是之后，所测参数均未改变。4. 有人提出：1）在我们的实验条件下，前列腺素E1和前列腺素F1α均未刺激肾素合成。消炎痛使肾素合成减少肯定是由对前列腺素E和前列腺素F以外的其他物质的抑制所引起的；2）前列腺素E在肾血流动力学和肾外分泌功能中的作用似乎很重要。

The PGE1, infused into the renal artery of the dog, increased RPF, Sodium and Potassium excretion rate and UV; it diminished the EPAH and FF but did not alter GFR and PRA. 2. The indomethacin, injected IV, in an other group of animals, decreased RPF, GFR, Sodium and Potassium excretion rate and PRA, and it increased the EPAH and FF. The administration of the PGE1, inversed the results obtained by indomethacin except those of PRA. 3. The infusion of the PGF1a, in other groups of dogs, did not alter either before or after the administration of indomethacin the parameters measured. 4. It was suggested that 1) neither the PGE1 nor the PGF1a stimulated renin synthesis, in the conditions that our experiments took place. The decrease of renin synthesis by indomethacin must be provoked by the inhibition of an other substance than the PGE and PGF and 2) the role of PGE in renal haemodynamic and exocrine renal function seems to be important.

将前列腺素E1注入狗的肾动脉，可增加肾血浆流量、钠和钾排泄率以及尿流量；它降低了对氨基马尿酸清除率和滤过分数，但未改变肾小球滤过率和血浆肾素活性。2. 在另一组动物中静脉注射消炎痛，可降低肾血浆流量、肾小球滤过率、钠和钾排泄率以及血浆肾素活性，并增加对氨基马尿酸清除率和滤过分数。给予前列腺素E1可逆转消炎痛所产生的结果，但血浆肾素活性的结果除外。3. 在其他几组狗中，注入前列腺素F1α，无论在给予消炎痛之前还是之后，所测参数均未改变。4. 有人提出：1）在我们的实验条件下，前列腺素E1和前列腺素F1α均未刺激肾素合成。消炎痛使肾素合成减少肯定是由对前列腺素E和前列腺素F以外的其他物质的抑制所引起的；2）前列腺素E在肾血流动力学和肾外分泌功能中的作用似乎很重要。

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