Giraud G D, MacCannell K L
J Pharmacol Methods. 1981 Aug;6(1):65-75. doi: 10.1016/0160-5402(81)90085-1.
A method which utilized the absorption of 125I as a measure of intestinal mucosal blood flow was developed. In the pentobarbital anesthetized dog a segment of mid-jejunum was isolated from adjacent vasculature and perfused with 125I solution. Superior mesenteric artery flow, blood flow to the isolated segment of intestine and 125I absorption were measured. Changes in 125I absorption were found to correlated closely with changes in blood flow (r = 0.95). Using an autoradiographic technique 125I absorption was found to be localized to the intestinal mucosa.
开发了一种利用¹²⁵I吸收来测量肠黏膜血流的方法。在戊巴比妥麻醉的犬中，将一段空肠中段与相邻血管分离，并用¹²⁵I溶液灌注。测量肠系膜上动脉血流、分离肠段的血流和¹²⁵I吸收情况。发现¹²⁵I吸收的变化与血流变化密切相关（r = 0.95）。使用放射自显影技术发现¹²⁵I吸收定位于肠黏膜。
