Scholz D A, Purnell D C
Mayo Clin Proc. 1981 Aug;56(8):473-8.
Because factual basic knowledge is lacking regarding the natural history of primary hyperparathyroidism, it has been impossible to make a reasonable prognostication of the risks inherent to judicious observation as a justifiable alternative to neck exploration in patients with mild asymptomatic and uncomplicated hyperparathyroidism. Therefore, in January 1968 a prospective study was initiated at the Mayo Clinic in an effort to provide more information regarding the natural history of this disease. The cumulative 10-year findings of this study are presented. On the basis of the findings, it was not possible to define criteria that will predict which patients with primary asymptomatic hyperparathyroidism will ultimately require surgery.
由于缺乏关于原发性甲状旁腺功能亢进自然病史的实际基础知识，对于轻度无症状且无并发症的甲状旁腺功能亢进患者，在颈部探查作为合理替代方案时，无法对审慎观察所固有的风险进行合理预测。因此，1968年1月，梅奥诊所启动了一项前瞻性研究，旨在提供更多关于该疾病自然病史的信息。本文展示了该研究累积10年的结果。基于这些结果，无法确定能够预测哪些原发性无症状甲状旁腺功能亢进患者最终需要手术的标准。
