肢端肥大症患者中阿片系统对生长激素分泌的异常调控：一项使用纳洛酮和2-溴-α-麦角隐亭（CB 154）的研究

Abnormal control of growth hormone secretion by opiate systems in acromegalic patients: a study with naloxone and 2-Br-alpha-ergocryptine (CB 154).

作者信息

Agnati L F, Benfenati F, Frank G, Capelli M, Bernardi P, Calza L

出版信息

Med Biol. 1981 Feb;59(1):58-63.

Abstract

The present study was undertaken with the aim of exploring the role that opiate systems may have in neuroendocrine control in acromegaly. The effects of naloxone (0.4 mg, i.m.), of 2-Br-alpha-ergocryptine (CB154, 2.5 mg, p.o.) and of the interaction between CB154 and naloxone on growth hormone (GH) and prolactin (PRL) secretion were studied in 11 acromegalic patients. CB154 reduced both GH and PRL serum levels, naloxone only GH serum levels. The latter effect deserves further study aimed at a possible new therapeutic approach to GH hypersecretion observed in acromegaly. Naloxone also interfered with the lowering effects of CB154 and GH and PRL serum levels, pointing to the existence of an interaction between dopaminergic and opiate control of GH and PRL secretion in acromegaly.

摘要

本研究旨在探讨阿片系统在肢端肥大症神经内分泌控制中可能发挥的作用。在11例肢端肥大症患者中，研究了纳洛酮（0.4mg，肌肉注射）、2-溴-α-麦角隐亭（CB154，2.5mg，口服）以及CB154与纳洛酮的相互作用对生长激素（GH）和催乳素（PRL）分泌的影响。CB154降低了GH和PRL的血清水平，纳洛酮仅降低了GH的血清水平。后一种效应值得进一步研究，以期找到针对肢端肥大症中GH分泌过多的可能新治疗方法。纳洛酮还干扰了CB154降低GH和PRL血清水平的作用，表明在肢端肥大症中，多巴胺能和阿片对GH和PRL分泌的控制之间存在相互作用。