Orio F, Iovino M, Monteleone P, Agrusta M, Steardo L, Lombardi G
Department of Endocrinology, General Hospital of Eboli, Salerno, Italy.
Horm Metab Res. 1988 Nov;20(11):701-4. doi: 10.1055/s-2007-1010921.
An extensive hypothalamic neurotransmitter impairment has been proposed in acromegaly. However, at the moment, the hypothalamic GABAergic system has been little investigated in this disorder. Since GABA has been shown to modulate growth hormone (GH) and prolactin (PRL) secretion in human subjects, it seemed reasonable to investigate hypothalamic GABAergic functioning through the assessment of basal GH and PRL responses to pharmacological activation of this system. 800 mg of sodium valproate (SV), a drug with GABA facilitating properties, were administered orally to 7 acromegalic patients and 9 healthy volunteers. Blood samples were collected before and after the drug administration for the measurement of plasma GH and PRL levels. SV induced a clear-cut rise in basal GH and a decrease in basal PRL in healthy subjects, but it did not induce any change in the basal levels of these hormones in acromegalics. These results suggest that the response of GH and PRL to SV in acromegaly is qualitatively different from normal controls.
肢端肥大症患者中已有人提出存在广泛的下丘脑神经递质损伤。然而，目前在这种疾病中对下丘脑γ-氨基丁酸（GABA）能系统的研究很少。由于GABA已被证明可调节人体生长激素（GH）和催乳素（PRL）的分泌，因此通过评估基础GH和PRL对该系统药物激活的反应来研究下丘脑GABA能功能似乎是合理的。向7例肢端肥大症患者和9名健康志愿者口服800毫克丙戊酸钠（SV），这是一种具有促进GABA作用的药物。在给药前后采集血样以测量血浆GH和PRL水平。SV使健康受试者的基础GH明显升高，基础PRL降低，但在肢端肥大症患者中并未引起这些激素基础水平的任何变化。这些结果表明，肢端肥大症患者中GH和PRL对SV的反应在性质上与正常对照组不同。
