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Effect of reduction and alkylation on structure and function of rabbit IgG antibody-I. Effect on ability to activate complement depends on conditions of reduction.

作者信息

Johnson B A, Hoffmann L G

出版信息

Mol Immunol. 1981 Mar;18(3):181-8. doi: 10.1016/0161-5890(81)90084-5.

DOI:10.1016/0161-5890(81)90084-5
PMID:7266486
Abstract
摘要

相似文献

1
Effect of reduction and alkylation on structure and function of rabbit IgG antibody-I. Effect on ability to activate complement depends on conditions of reduction.还原和烷基化对兔IgG抗体结构和功能的影响-I。对补体激活能力的影响取决于还原条件。
Mol Immunol. 1981 Mar;18(3):181-8. doi: 10.1016/0161-5890(81)90084-5.
2
Effect of reduction and alkylation on structure and function of rabbit IgG antibody--II. Effects on classical pathway C3 convertase formation.还原和烷基化对兔IgG抗体结构与功能的影响——II. 对经典途径C3转化酶形成的影响
Mol Immunol. 1984 Jan;21(1):77-87. doi: 10.1016/0161-5890(84)90092-0.
3
Importance of the integrity of the inter-heavy-chain disulphide bond of rabbit IgG in the activation of the alternative pathway of human complement by the F(ab')2 region of rabbit IgG antibody in immune aggregates.兔IgG重链间二硫键完整性在兔IgG抗体F(ab')2区域于免疫聚集体中激活人补体替代途径中的重要性。
Immunology. 1981 Jan;42(1):75-82.
4
Contributions of heavy and light chains of rabbit immunoglobulin G to antibody activity. II. Binding activities of reconstituted immunoglobulins.
Biochemistry. 1972 Apr 11;11(8):1338-45. doi: 10.1021/bi00758a002.
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The structure and function of immunoglobulin domains. II. The importance of interchain disulfide bonds and the possible role of molecular flexibility in the interaction between immunoglobulin G and complement.免疫球蛋白结构域的结构与功能。II. 链间二硫键的重要性以及分子柔性在免疫球蛋白G与补体相互作用中的可能作用。
J Immunol. 1975 Jun;114(6):1726-9.
6
Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond.重链间二硫键还原后IgG四级结构的变化。
Proc Natl Acad Sci U S A. 1979 Feb;76(2):907-11. doi: 10.1073/pnas.76.2.907.
7
Structural requirements of rabbit IgG F(ab')2 fragment for activation of the complement system through the alternative pathway--I. Disulfide bonds.兔IgG F(ab')2片段通过替代途径激活补体系统的结构要求——I. 二硫键
Mol Immunol. 1981 Oct;18(10):925-34. doi: 10.1016/0161-5890(81)90015-8.
8
Reduced immunoglobulin G activates complement system with decreased cooperativity.免疫球蛋白G减少会以降低的协同性激活补体系统。
Biochem Biophys Res Commun. 1978 Aug 29;83(4):1284-90. doi: 10.1016/0006-291x(78)91360-8.
9
Spontaneous re-aggregation of IgM subunits and restoration of antibody activity after reduction and alkylation of rabbit anti-Forssman antibody.兔抗福斯曼抗体还原烷基化后IgM亚基的自发重新聚集及抗体活性的恢复
Immunology. 1969 Aug;17(2):237-47.
10
The kinetics of clearance of human antibody/dsDNA immune complexes from rabbit circulation. Effects of dsDNA size, rheumatoid factor, and reduction and alkylation of the antibodies.人抗体/双链DNA免疫复合物从兔循环中清除的动力学。双链DNA大小、类风湿因子以及抗体的还原和烷基化的影响。
J Immunol. 1986 May 15;136(10):3785-92.

引用本文的文献

1
Disulfide bond structures of IgG molecules: structural variations, chemical modifications and possible impacts to stability and biological function.IgG 分子的二硫键结构:结构变异、化学修饰以及对稳定性和生物学功能的可能影响。
MAbs. 2012 Jan-Feb;4(1):17-23. doi: 10.4161/mabs.4.1.18347.
2
Quantitative analysis of the interaction between immune complex and C1q complement subcomponent. The role of interdomain interactions in rabbit IgG in binding of C1q to immune precipitates.免疫复合物与C1q补体亚成分相互作用的定量分析。兔IgG中结构域间相互作用在C1q与免疫沉淀物结合中的作用。
Biochem J. 1987 Apr 15;243(2):449-55. doi: 10.1042/bj2430449.