Kádas I, Péley I
Morphol Igazsagugyi Orv Sz. 1981 Apr;21(2):135-41.
Clinical differential diagnosis of neonatal icteric diseases not infrequently appears to be difficult. Diagnostic means are limited. The needle biopsy of the liver has become an important aid in the diagnosis of neonatal liver diseases. Authors have analysed 21 biopsies obtained from children with congenital bile duct atresia and 8 biopsies from children with cholestatic hepatosis. Findings are compared with those revealed in neonatal hepatitis and other processes. The early changes (intracanalicular and intraductal cholestasis) are similar both in congenital bile duct atresia and in cholestatic hepatosis. In the later phase of the process in cholestatic hepatosis and in other diseases increasing cholestasis and a secondary damage to the parenchyma, but first of all portal changes came into being and gave a reliable basis for the differential diagnosis. Liver biopsy is indispensable for the diagnosis of mentioned diseases.
新生儿黄疸性疾病的临床鉴别诊断常常显得困难。诊断手段有限。肝脏穿刺活检已成为诊断新生儿肝脏疾病的一项重要辅助手段。作者分析了21例先天性胆管闭锁患儿的肝脏活检标本以及8例胆汁淤积性肝病患儿的活检标本。将结果与新生儿肝炎及其他病症的结果进行了比较。早期变化（肝内胆管和导管内胆汁淤积）在先天性胆管闭锁和胆汁淤积性肝病中相似。在胆汁淤积性肝病及其他疾病病程的后期，胆汁淤积加重，实质出现继发性损害，但首先出现的是门静脉变化，这为鉴别诊断提供了可靠依据。肝脏活检对于上述疾病的诊断不可或缺。
