多巴胺拮抗剂对雄性大鼠垂体中DNA合成的调节作用。

Modulation by dopamine antagonists of DNA synthesis in the pituitary gland of the male rat.

作者信息

Jacobi J M, Lloyd H M

出版信息

Neuroendocrinology. 1981 Aug;33(2):97-100. doi: 10.1159/000123210.

Abstract

Pituitary DNA synthesis and serum and pituitary concentrations of prolactin were measured in male rats given the dopamine antagonist haloperidol or pimozide, and the dopamine agonist bromocriptine. Increased DNA synthesis was observed 25h after a single injection of haloperidol and on each day of the 5-day period of pimozide administration. Haloperidol and pimozide increased serum prolactin levels. Pituitary prolactin concentrations fell 12h after haloperidol, recovering b6 24h, and 24 and 48h after pimozide, recovering by 72 h. Bromocriptine lowered pituitary DNA synthesis and serum prolactin levels and induced a transient rise in pituitary prolactin concentrations. The results indicate that dopamine agonists and antagonists modulate DNA synthesis in the pituitary gland of the rat.

摘要

对给予多巴胺拮抗剂氟哌啶醇或匹莫齐特以及多巴胺激动剂溴隐亭的雄性大鼠，测定其垂体DNA合成以及血清和垂体中的催乳素浓度。单次注射氟哌啶醇25小时后以及在给予匹莫齐特的5天期间的每一天，均观察到DNA合成增加。氟哌啶醇和匹莫齐特可提高血清催乳素水平。氟哌啶醇给药后12小时垂体催乳素浓度下降，24小时恢复；匹莫齐特给药后24小时和48小时垂体催乳素浓度下降，72小时恢复。溴隐亭可降低垂体DNA合成和血清催乳素水平，并导致垂体催乳素浓度短暂升高。结果表明，多巴胺激动剂和拮抗剂可调节大鼠垂体中的DNA合成。