Boullin D J, Aitken V, du Boulay G H, Tagari P
Neuroradiology. 1981;21(5):245-52. doi: 10.1007/BF02100154.
Rupture of human cerebral arterial aneurysms is followed by prolonged cerebral arterial constriction; there is evidence that cerebrospinal fluid (CSF) from such patients contains vasoconstrictor substances which may cause the arterial constriction. The aim of this study was to develop a small animal model for investigating the effects of such CSF on the calibre of cerebral vessels in situ. Carotid angiography of the cerebral arteries of the rat visualizes the internal carotid, middle cerebral, anterior cerebral and stapedial arteries plus the vertebrobasilar system. Prostacyclin was injected during carotid catheterisation to prevent spontaneous and random occlusion of these cerebral arteries; in the presence of prostacyclin there was no arterial occlusion for up to 5 h. The resolution achieved by the angiographic technique, which magnified the cerebral circulations 2.9 times, was sufficient to measure the diameter of the internal carotid and stapedial arteries of the rat. Intracarotid infusion of 1.0 ml CSF collected from patients with ruptured cerebral arterial aneurysms caused a rapidly developing contraction of cerebral arteries lasting up to 5 h. Thus, we consider that the rat may also be used as a model for investigating the aetiology of human cerebral arterial constriction after aneurysmal rupture.
人脑动脉动脉瘤破裂后会出现长时间的脑动脉收缩；有证据表明，此类患者的脑脊液（CSF）中含有可能导致动脉收缩的血管收缩物质。本研究的目的是建立一种小动物模型，用于研究这种脑脊液对原位脑血管管径的影响。大鼠脑动脉的颈动脉血管造影可显示颈内动脉、大脑中动脉、大脑前动脉和镫骨动脉以及椎基底系统。在进行颈动脉插管时注射前列环素，以防止这些脑动脉自发和随机闭塞；在有前列环素的情况下，长达5小时内没有动脉闭塞。血管造影技术将脑循环放大了2.9倍，其分辨率足以测量大鼠颈内动脉和镫骨动脉的直径。经颈动脉注入从人脑动脉动脉瘤破裂患者收集的1.0 ml脑脊液，会导致脑动脉迅速收缩，持续长达5小时。因此，我们认为大鼠也可作为研究动脉瘤破裂后人脑动脉收缩病因的模型。
