大鼠下橄榄核-攀缘纤维与对，对'-滴滴涕诱导的肌阵挛的关系。

Relationship of inferior olive-climbing fibers to p,p'-DDT-induced myoclonus in rats.

作者信息

Hwang E C, Plaitakis A, Magnussen I, Van Woert M H

出版信息

Neurosci Lett. 1981 Jun 12;24(1):103-8. doi: 10.1016/0304-3940(81)90367-0.

Abstract

The effects of 3-acetylpyridine (3-AP), which destroys the inferior olive, and harmaline, which stimulates inferior olive-climbing fiber activity, on DDT-induced myoclonus, wee studied in rats. 3-AP shortened and harmaline delayed the time of onset of myoclonus after intragastric administration of DDT. 3-AP also counteracted the antimyoclonic action of L-5-hydroxytryptophan plus chlorimipramine, clonazepam and phenoxybenzamine in this animal model. The results suggest that these antimyoclonic agents require an intact olivocerebellar pathway for their action.

摘要

我们研究了破坏下橄榄核的3-乙酰吡啶（3-AP）和刺激下橄榄核-攀缘纤维活动的哈马灵对大鼠DDT诱导的肌阵挛的影响。胃内给予DDT后，3-AP缩短了肌阵挛的发作时间，而哈马灵则延迟了发作时间。在该动物模型中，3-AP还抵消了L-5-羟色氨酸加氯米帕明、氯硝西泮和酚苄明的抗肌阵挛作用。结果表明，这些抗肌阵挛药物的作用需要完整的橄榄小脑通路。