多巴胺诱导的大鼠呼吸抑制，由颈动脉神经传入介导。

Dopamine-induced ventilatory depression in the rat, mediated by carotid nerve afferents.

作者信息

Cardenas H, Zapata P

出版信息

Neurosci Lett. 1981 Jun 12;24(1):29-33. doi: 10.1016/0304-3940(81)90354-2.

Abstract

In pentobarbitone-anesthetized rats, i.v. injections of dopamine (DA) at (10-8)-(10-5 g/kg led to transient ventilatory depression, usually not associated with changes in systemic arterial pressure. DA-induced ventilatory depression consisted of decreases in tidal volume and respiratory frequency in 12 rats, and in bradypnea without changes in tidal volume in 5 rats. After bilateral section of the carotid nerves, ventilatory responses to DA were abolished or greatly diminished. It is concluded that DA inhibits carotid body chemosensory discharges in the rat. The possibility that chemosensory activity directly affects respiratory frequency is discussed.

摘要

在戊巴比妥麻醉的大鼠中，静脉注射剂量为(10-8)-(10-5)克/千克的多巴胺（DA）会导致短暂的通气抑制，通常与体循环动脉压的变化无关。DA诱导的通气抑制在12只大鼠中表现为潮气量和呼吸频率降低，在5只大鼠中表现为呼吸过缓且潮气量无变化。双侧切断颈动脉神经后，对DA的通气反应消失或大大减弱。得出的结论是，DA抑制大鼠颈动脉体的化学感受性放电。还讨论了化学感受活动直接影响呼吸频率的可能性。