Zapata P, Zuazo A
Respir Physiol. 1980 Apr;40(1):79-92. doi: 10.1016/0034-5687(80)90006-7.
In pentobarbitone-anesthetized cats, intracarotid injections of dopamin (DA) 0.05--20 micrograms produced transient ventilatory depression, enhanced by section of the contralateral carotid nerve and abolished by section of the ipsilateral one. I.v. injections of DA 0.02--2 micrograms-kg-1 also induced transient hypoventilation; this effect was abolished by bilateral section of the carotid nerves. Slow i.v. infusion of DA 10 micrograms-kg-1-min-1 elicited initially a pronounced hypoventilation followed by a steady-state of mild ventilatory depression; these changes were absent after bilateral carotid neurotomy. Recordings from carotid nerves showed that DA-induced decreases of chemosensory activity to 50% of its control did not modify ventilation, while chemosensory arrests transiently depressed ventilation to 40--75% of its control level. Interactions between the ventilatory and chemosensory depressant effects of hypertoxia and DA administration were also studied. It is proposed that the reflex decrease in ventilation caused by DA injections provides a measure of the tonic chemosensory drive exerted upon the respiratory center.
在戊巴比妥麻醉的猫中，颈内注射0.05 - 20微克多巴胺（DA）会产生短暂的通气抑制，对侧颈神经切断会增强这种抑制，同侧颈神经切断则可消除这种抑制。静脉注射0.02 - 2微克·千克⁻¹的DA也会引起短暂的通气不足；双侧颈神经切断可消除这种效应。以10微克·千克⁻¹·分钟⁻¹的速度缓慢静脉输注DA，最初会引起明显的通气不足，随后是轻度通气抑制的稳定状态；双侧颈动脉神经切断后则不会出现这些变化。对颈神经的记录显示，DA诱导的化学感受活动降低至对照值的50%时并不会改变通气，但化学感受活动的停止会使通气暂时降低至对照水平的40 - 75%。还研究了高氧和DA给药对通气和化学感受抑制作用之间的相互作用。有人提出，DA注射引起的通气反射性降低提供了一种衡量对呼吸中枢施加的紧张性化学感受驱动的方法。
