脑啡肽在苍白球的体内释放。

In vivo release of enkephalin from the globus pallidus.

作者信息

Bayon A, Shoemaker W J, Lugo L, Azad R, Ling N, Drucker-Colin R R, Bloom F E

出版信息

Neurosci Lett. 1981 Jun 12;24(1):65-70. doi: 10.1016/0304-3940(81)90360-8.

Abstract

Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the perfusing medium. Local perfusion with veratrine also enhanced enkephalin release. Furthermore, in vivo, electrical stimulation of the rat caudo-putamen enhanced enkephalin release in the pallidum. This latter finding is consistent with a functional strio-pallidal enkephalin-containing pathway previously postulated by immunohistochemical or lesion experiments.

摘要

将推挽式套管经预先植入未麻醉自由活动猫和大鼠苍白球的引导管急性定位。在缓慢灌注过程中，检测到静息状态下的脑啡肽释放，当灌注液中同时存在50 mM K⁺和1.8 mM Ca²⁺时，脑啡肽释放增加超过3倍。用藜芦碱局部灌注也增强了脑啡肽释放。此外，在体内，电刺激大鼠尾壳核可增强苍白球中的脑啡肽释放。后一发现与先前通过免疫组织化学或损伤实验推测的功能性含脑啡肽的纹状体 - 苍白球通路一致。